Water-Soluble Constituents of Fennel. VIII. Monoterpenoid Alcohols and Thujane-, Camphane-, Norfenchane-Type Monoterpenoid Glycosides.
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چکیده
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Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols.
Morphine is an important drug used to alleviate moderate to severe pain. This opiate is mainly metabolized by glucuronidation to a non-analgesic metabolite, morphine-3-glucuronide (M-3-G) and an active metabolite morphine-6-glucuronide (M-6-G). To understand the modulation of morphine glucuronidation activity by environmental factors, the effect of endogenous and food-derived compounds on morph...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1999
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.47.805